Peritoneal mesothelioma

Dr Daniel J Bell◉ and Dr Alexandra Stanislavsky◉ et al.

Peritoneal mesothelioma is an uncommon primary tumour of the peritoneal lining. It shares epidemiological and pathological features with but is less common than its pleural counterpart, which is described in detail in the general article on mesothelioma. Other subtypes (also discussed separately) include:

Epidemiology

abdominal mesothelioma

Approximately 20-30% of all mesotheliomas arise from the peritoneal serosal lining. As with pleural mesothelioma, there is also a strong association with asbestos exposure (primarily the crocidolite variety), and this occupational hazard probably accounts for disease predominance in middle aged to older males (most common age group is 50 to 70 years and it may also account for the slightly increased male predilection).

Despite this, ~50% of cases have no history of exposure to asbestos, although prior radiation exposure, exposure to thorium, talc, erionite or mica, as well as in patients affected by familial Mediterranean fever and diffuse lymphocytic lymphoma have also been reported.

The overall incidence is approximately 1-2 cases per million.

Clinical presentation

Typically patients present with weight loss, anorexia, abdominal pain and/or abdominal distension, pyrexia of unknown origin.

There can be symptoms associated with hypercoagulability particularly due to a paraneoplastic syndrome associated with mesothelioma.

There is a reported correlation between the clinical presentation and CT findings, with subgrouping into 2:

dry-painful type: presenting with abdominal pain, CT features of peritoneal mass(es) and little to no ascites
wet type: presenting with abdominal distension, CT findings of ascites and widespread nodules without a predominant mass
mixed type: both pain and ascites present

Pathology

As with pleural mesothelioma, three histologic subtypes exist:

epithelial (most frequent)
sarcomatoid
biphasic (mixed epithelial-sarcomatoid)

Radiographic features

Ultrasound

variable sonographic appearances, from sheet-like hypoechoic to echogenic masses 1,4
omental thickening
ascites

CT

CT is useful for the detection, characterization, staging, and guiding biopsy of peritoneal masses. Features include:

solid, heterogeneous, enhancing soft tissue mass
presence of calcified pleural plaques, indicative of asbestos exposure
in contrast, peritoneal tumoral calcification is uncommon
nodular, irregular peritoneal and omental thickening, progressing to omental caking
peritoneal or omental masses
variable ascites (mild to moderate)
direct invasion of abdominal viscera, especially liver and colon.
concurrent pleural involvement is not uncommon on CT images at diagnosis 7

Peritoneal mesothelioma does not tend to spread to distant organs and lymphadenopathy is usually not a feature.

MRI

Peritoneal masses and nodules demonstrate1:

T1: low-intermediate signal
T2: high signal
C+ (Gd): shows enhancement

Nuclear medicine

gallium scan: diffuse uptake throughout the peritoneal cavity 4

Treatment and prognosis

Treatment options include cytoreductive surgery, peritonectomy and intraperitoneal chemotherapy. However, the prognosis is very poor, with death usually within one year 6.

Differential diagnosis

General considerations include:

peritoneal carcinomatosis
- most common cause of omental nodules/caking
- more likely to contain dystrophic calcification
pseudomyxoma peritonei
lymphoma with peritoneal involvement
peritoneal involvement with tuberculosis
mesenteric panniculitis (retractile mesenteritis)

https://radiopaedia.org/articles/peritoneal-mesothelioma

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